Camostat Monomethanesulfonate
Camostat
CAS: 59721-28-7
Molecular Formula: C20H22N4O5
Camostat Monomethanesulfonate - Names and Identifiers
| Name | Camostat |
| Synonyms | Camostat CAMOSTAT Camostat Monomethanesulfonate 2-(Dimethylamino)-2-oxoethyl 4-(4-guanidinobenzoyloxy)phenylacetate 4-{2-[2-(dimethylamino)-2-oxoethoxy]-2-oxoethyl}phenyl 4-[(diaminomethylidene)amino]benzoate 4-[[4-[(Aminoiminomethyl)amino]benzoyl]oxy]benzeneaxetic acid 2-(dimethylamino)-oxoethyl ester 4-[[4-[(Aminoiminomethyl)amino]benzoyl]oxy]benzeneacetic acid 2-(dimethylamino)-2-oxoethyl ester |
| CAS | 59721-28-7 |
| InChI | InChI=1/C20H22N4O5/c1-24(2)17(25)12-28-18(26)11-13-3-9-16(10-4-13)29-19(27)14-5-7-15(8-6-14)23-20(21)22/h3-10H,11-12H2,1-2H3,(H4,21,22,23) |
Camostat Monomethanesulfonate - Physico-chemical Properties
| Molecular Formula | C20H22N4O5 |
| Molar Mass | 398.41 |
| Density | 1.28±0.1 g/cm3(Predicted) |
| Boling Point | 590.5±60.0 °C(Predicted) |
| Flash Point | 337.6°C |
| Vapor Presure | 5.22E-16mmHg at 25°C |
| pKa | 10.17±0.10(Predicted) |
| Refractive Index | 1.596 |
| Physical and Chemical Properties | Camostat Mesylate: C20H22N4O5? CH3SO3H. [59721-29-8]. Crystallized from methanol-diethyl ether, melting point 150-155 °c. Soluble in water. Acute toxicity LD50 mice, rats (mg/kg):4040-4500,4392-4720 oral. |
Camostat Monomethanesulfonate - Reference Information
| use | non-peptide protease inhibitor has strong inhibitory effect on trypsin, kallikrein, plasmin, thrombin and esterase, the first component of complement. For the relief of acute symptoms of chronic pancreatitis. |
| Production method | p-hydroxyphenylacetic acid and N,N-dimethyl bromoacetamide react in acetonitrile and triethylamine to obtain compound (I). Then react with 4-guanidinyl benzoyl chloride to obtain carmostat. |
Last Update：2024-04-09 21:04:16
